Comparative experimental study of 5-ALA and 5-ALA hexyl ester specific activity
نویسندگان
چکیده
منابع مشابه
Current Applications of 5-ALA in Glioma Diagnostics and Therapy
Gliomas, the most common primary brain tumors, are characterized by rapid proliferation, marked infiltration, and poor prognosis and are known for their dismal outcomes (Iacob & Din‐ ca, 2009; Lefranc et al., 2006). The infiltrative nature of malignant glioma makes complete resec‐ tion difficult, as tumor margins are unclear. Recurrence of glioma takes place within approximately 2 cm of the mar...
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Malignant gliomas are extremely difficult to treat with no specific curative treatment. On the other hand, photodynamic medicine represents a promising technique for neurosurgeons in the treatment of malignant glioma. The resection rate of malignant glioma has increased from 40% to 80% owing to 5-aminolevulinic acid-photodynamic diagnosis (ALA-PDD). Furthermore, ALA is very useful because it ha...
متن کاملPhotodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)
In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independen...
متن کامل5-Aminolevulinic Acid (5-ALA): Analysis of Preclinical and Safety Literature
Problem: 5-ALA has been used for many years at relatively high dose amounts in single doses for photodynamic therapy and immunofluorescence of tumors. An analysis of compiled data relating to safety and any side-effects about the use of 5-ALA at low doses has not yet been published. Purpose: This report analyzes data about the safety of the use of 5-Aminolevulinic Acid (5-ALA) in low doses as a...
متن کاملRegulation of 5-Aminolevulinic Acid (ALA) Synthesis in Developing Chloroplasts : III. Evidence for Functional Heterogeneity of the ALA Pool.
Gabaculine and 4-amino-5-hexynoic acid (AHA) up to 3.0 millimolar concentration strongly inhibited 5-aminolevulinic acid (ALA) synthesis in developing cucumber (Cucumis sativus L. var Beit Alpha) chloroplasts, while they hardly affected protochlorophyllide (Pchlide) synthesis. Exogenous protoheme up to 1.0 micromolar had a similar effect. Exogenous glutathione also exhibited a strong inhibitory...
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ژورنال
عنوان ژورنال: Biomedical Photonics
سال: 2018
ISSN: 2413-9432
DOI: 10.24931/2413-9432-2018-7-3-43-46